Alterations of this two-story structure for the main seminary building required dividing it into two chapels and 15 other rooms. This site, and other structures located on the extensive grounds, provided classroom space and dormitory facilities for the students. Prior to the Civil War, the seminary had boasted nearly 40 students per year, but, like many local institutions, the seminary could not rise above the economic hardships incurred by the Battle of Perryville.
When Confederate armies invaded Kentucky in the summer of 1862, they commandeered the seminary to house sick Southern soldiers. The situation worsened when, on Oct. 8, 1862, the Battle of Perryville left more than 7,500 troops killed and wounded.
In its aftermath, area communities cared for wounded troops, and Danville's spacious seminary became a main hospital site. Two additional buildings on the grounds, a five-room frame structure and a small brick building, also housed patients. Tents were scattered across the lawn, and residents frequently saw recovering soldiers sitting on benches placed under trees on the property.
Most area hospitals housed either Northern or Southern patients, yet wounded and sick from both sides were jammed into the main seminary building. Rebel surgeons received permission to remain in town to care for wounded Confederates who were, nevertheless, prisoners of war. Local housekeeper Mary Harris, who nursed the injured and wrote letters home for many of the soldiers, said, "I was in that building every day, and I bathed the brow of many a soldier in there, both Federal and Confederate."
The enemy troops did not intermingle. Union troops piled into the west side of the structure, while the Southerners crammed into the eastern end. Danville tailor Abraham Barker had a theory for this separation. He believed that "They had them in different sides to keep them, I reckon, from fighting. ..."
When Dr. A.N. Read of the United States Sanitary Commission visited five of the seminary rooms in mid-October, he noted that 79 wounded were packed into them. All of these patients had beds (unlike many of the Danville hospitals) and 26 nurses provided care for them.
When Read returned to tour the entire site at the end of the month, he found that the seminary was "occupied half by Federal and half by Rebel sick. Of the Federal there were 95 in two rooms ... (with) men generally on bunks, no bedsacks, no pillows, some without blankets; their clothing, such as they had worn in the field (was) generally much soiled; cooking done in the open air in a few camp kettles. Confederates in 10 rooms ... Their condition similar to that of the Federals, except things were more filthy, their clothing much poorer."
The sick likely suffered from the common 19th century military ailments: typhoid, pneumonia and dysentery. Furthermore, many of the wounded were in critical condition. Read reported that those in the seminary "were all badly wounded."
In addition, Mary Harris testified, "They were all to pieces - some of them shot to pieces, some of them with shell and some with buffets; there were amputations."
Dr. Read believed that of the Danville hospitals, including the courthouse and most churches, the seminary was "the best of the series," because all of the other hospitals were "far too much crowded."
"When this Seminary property was finally vacated as a hospital, it was pretty badly done up, very much abused," reported Danville citizen E.E. Akin. "Everything was out of order. ... I didn't see anything that was in order, anything that hadn't been very roughly used. The walls knocked (in), and plastering off, and (wall) paper injured, and windows broken."
Mary Harris noted, "The fencing was all gone, it was fenced around, and that was all gone. The walls and windows were defaced. There were a good many lights out."