Mercer shot 46.7 percent (35-for-75) from the field and was a sizzling 10-for-22 from 3-point range and 10-for-13 at the free-throw line.
The Lady Scotties led 46-16 at halftime after Harrodsburg (3-13, 0-6) scored just four points in the second quarter.
Chrystal Claunch had 13 points and eight assists for Mercer, while Claunch, Erin Ashford and Cala Alford had five rebounds each.
Tiffany Smith and Sarah Roach led Harrodsburg with 11 and 10 points, respectively.
HARRODSBURG (3-13) - Tiffany Smith 11, Mandy Long 9, Laila Graves 4, Sarah Roach 10, Annie Sutton 4, Jasmine Brown 1.
MERCER (13-5) - Courtney Watts 23, Chrystal Claunch 13, Chelsea Goodman 26, Erin Ashford 9, Jillian Horn 2, Erica Lee 6, Cala Alford 4, Krysta Honchel 2, Tara Camden 2, McKenzie Carey 3.
Garrard County 70, Burgin 40 - At Lancaster, Garrard (8-9, 4-1 46th District) enjoyed one of its best shooting nights of the season, hitting 55.3 percent from the field to defeat Burgin (9-8, 2-4).
The Lady Lions got off to a fast start, outscoring Burgin 22-5 in the first quarter, and they started the second half strong as well by outscoring Burgin 21-5 to take a 57-18 lead en route to their fifth straight win.
"We just came out strong in the first quarter and third quarter and shot the ball really well, and we played pretty good defense," Garrard coach Jenny Teater said.
Burgin coach Keith Monson said there was nothing pretty about the way his team played.
"We just didn't show up to play," Monson said. "I really was disappointed with our effort. We've been playing pretty good up to this point, and I really thought we'd be ready to play.
"Evidently we had to buy tickets to get into the game."
Burgin shot 24 percent (12-for-50) from the field, going just 5-for-17 from the field and 11-for-21 at the free-throw line, and the Lady Bulldogs had 17 turnovers.
Garrard was 26-for-47 from the field, 2-for-4 from 3-point range and 12-for-18 at the line.
Ashley Meadows and Chelsea Denny were perfect from the field for Garrard. Meadows was 8-for-8 and scored a game-high 17 points, while Denny was 4-for-4 and had nine points.
Kia Howard and Andrea Adams had six rebounds each to help the Lady Lions outrebound Burgin 33-23.
Burgin got 12 points and 10 rebounds from Taylor Bottoms and 11 points from Bev Harris. Amanda Carey got all nine of her points in the fourth quarter, when she was 3-for-3 from 3-point range.
BURGIN (9-8) - Taylor Bottoms 12, Stephanie Stewart 1, Bev Harris 11, Clara Sanders 5, Meredith Lear 2, Amanda Carey 9.
GARRARD (8-9) - Kia Howard 3, Andrea Adams 9, Abby Parsons 8, Chelsea Denny 9, Kalyn Payton 4, Ashley Meadows 17, Wendy Logan 4, Jessica Cole 4, Sydney Napier 9, Tamera Rothwell 3.
Somerset 62, Boyle County 43 - At Danville, Boyle coach Judie Mason lost her first meeting against her former team and the Lady Rebels (4-11) lost their seventh consecutive game.
Madison Flowers had 18 points to lead Somerset, the team Mason coached until leaving for Boyle this season.
Boyle was within striking distance until the fourth quarter, when Somerset outscored the Lady Rebels 17-6 to pull away.
Ashley Chalk had 11 points and Michelle Yates added 10 to lead Boyle. Allie Hafley had a team-high four rebounds - Boyle had only 20 - and Hafley and Yates each hit two 3-pointers.
SOMERSET (9-11) Cowan 5, Flowers 18, K. Stevenson 7, M. Stevenson 5, Irvin 16, Clay 8, Gomez 3.
BOYLE (4-11) - Hafley 8, Chalk 11, Edmiston 5, Anderson 8, Yates 10, Sarah Hall 1.