Hoffman said Centre got exceptional play from defender Laura Heil and midfielder Maggie Ray.
The Colonels, playing their last game before a 12-day layoff, outshot Oglethorpe 23-2. Goalkeeper Erin Haney needed to make only one save for her first shutout of the season.
At Atlanta, Centre's postseason hopes took a serious hit with a 3-0 loss to Oglethorpe.
The Colonels (8-3-1, 3-1-1 SCAC) outshot Oglethorpe 19-7, but coach Jeb Burch said only one of them was fired directly at the goal. Centre missed two point-blank shots, both from about 5 yards out, in the first five minutes.
Burch said the Colonels were feeling the effects of 16 hours of bus travel on their weekend trip to Millsaps and Oglethorpe.
"I think we certainly showed our legs a little bit today," he said. "We really couldn't connect on any passes.
"This was a very tough loss. This isn't one of those games where we had anything to learn; it's just a stark reality of the travel we had to go through. I know our kids will bounce back."
Anthony Thompson gave Oglethorpe (7-5, 4-2) a 1-0 lead with a first-half goal, and Frank Monteleone and Jonathan McConnell scored in the second half for the Stormy Petrels.
At Atlanta, Centre closed a series of five matches against SCAC Western Division schools at 3-2 with a 30-24, 30-18, 30-19 win over Hendrix and ended the weekend in a fourth-place tie.
The Colonels (15-7, 5-4 SCAC) used strong serving to rattle Hendrix (7-16, 2-7). They had 10 service aces, three by Megan McElveen and two each by Lisa Fryman and Leah Ballinger.
"We did a great job serving," Centre coach Stephanie Dragan said. "(It) was great to see that we had the confidence to come out and serve tough."
Sarah Burger had 13 kills and no errors in 19 attack attempts for a .684 attack percentage, and Danielle Norman had 11 kills and three errors in 22 attempts. Burger also had four solo blocks and two block assists, Ballinger had 36 defensive assists and McElveen had 12 digs.