Centre opened Friday with a 30-19, 30-23, 30-25 loss to No. 7 Trinity.
"They are so strong, and they're No. 7 in the country for a reason," Centre coach Stephanie Dragan said. "We would shut down one facet of their game and they would just turn up another one."
But Dragan said Centre defender Megan McElveen, who had 19 digs, held her own.
"Megan was basically in kamikaze defense back there, and she did a great job," Dragan said.
Sarah Burger had 12 kills, and Leah Ballinger had 30 assists and two aces.
Centre came back to defeat Hendrix 30-18, 30-16, 30-22, getting five solo blocks and two assists from Shannon Stribos.
McElveen had 14 digs, Ballinger had 36 assists and Whitney Faust had nine kills and three aces.
On Saturday, Centre saw its last hope for postseason play fade away with a 30-21, 30-16, 30-14 loss to Southwestern, which was also fighting for its postseason life.
Southwestern had 79 digs in three games.
"Today they were just a better, bigger, faster team than we were, and it was very disappointing," Dragan said.
Ballinger had 30 assists, McElveen had 17 digs and Burger had 13 kills.
With nothing left to play for, Centre then lost 30-25, 34-32, 21-30, 26-30, 19-17 to Millsaps.
Ellie Exner had a career-high 30 digs. Ballinger had 50 assists; Stribos had two solo blocks and six assists.
Centre plays Rhodes today.
At Sewanee, Tenn., Centre closed its season with a 3-2 loss to Sewanee after giving up a pair of second-half goals.
Centre (3-8-3) led 1-0 when Nikki Hollabaugh scored off a pass from Clay McCollum 5:21 into the game, but Sewanee (14-4) tied the game on a penalty kick later in the first half.
The Tigers scored twice in five minutes early in the second half. Centre got one more goal when Laura Heil headed Maggie Ray's corner kick into the goal.
Centre coach Jay Hoffman said he hopes his seniors' efforts this season will pay off in the future.
"Hopefully their hard work will be the roots for future players that go through Centre College," he said.
At Sewanee, Tenn., Centre ended its season with a 2-1 win over Sewanee thanks to goals by Chas Werner and Stan Simek.