Jayme Davis had 15 points, nine rebounds and two steals.
The Colonels (2-3) shots 46.5 percent (20-for-43) from the field and limited Maryville to 31.7 percent (20-for-63). Centre was 21-for-29 at the foul line.
"We were up by as many as 16 points before Maryville made a run at us, but we hit some big free throws to put the game away," Ruff-Osborne said.
Centre 59, North Carolina Wesleyan 53 - In the Food County Invitational at Emory, Va., Centre's men relied on defense to win.
"Defense has been carrying us and did again today," Centre coach Greg Mason said. "We held them to 33.9 percent shooting and outrebounded them by three. They were also a quick team, but we had only 12 turnovers and that was a big key because we did a good job setting the tempo."
Center Reggie Magnusson, who was named to the all-tournament team, led Centre with 14 points and six rebounds. Kyle Roby added 12 points, three assists and one steal. Cory Zerhusen had 10 points.
The Colonels (4-1) were only 22-for-63 from the field, including 3-for-23 from 3-point range. Centre did go 12-for-14 at the foul line.
"Reggie really had another good game for us, especially in the second half," Mason said. "Roby and (Thomas) Britt both played good floor games for us and made some key plays that helped us grind out a win on a day where we didn't shoot very well."