Spiller scored three plays after Clemson linebacker Kavell Conner stripped Gene McCaskill after a short catch and Jarvis Jenkins recovered the ball at the Kentucky 19 for the game's only turnover.
Kentucky tried to answer.
Punter Ryan Tydlacka ran for 9 yards on fourth-and-3, then Brooks used his last timeout with 5:38 left before going for it again on fourth-and-8 at the Clemson 32. The Cats couldn't convert. Freshman quarterback Morgan Newton scrambled only to be tackled by Ricky Sapp a yard short.
Spiller helped the Tigers run out the clock and start the celebration. He finished with 68 yards on 15 carries and 57 yards on three catches to earn game MVP honors.
But the Wildcats did a decent job of slowing down one of the country's most dynamic players. He became the first ACC player to rush for at least 1,000 yards and have at least 500 yards receiving in the same history at the end of the third quarter when he took a shovel pass 3 yards.
He didn't return a kick longer than 30 yards. Kentucky kicker Lones Seiber perfectly placed one kickoff into the right edge of the end zone near the pylon for a touchback, and Spiller caught another near the same spot for another touchback.
Kentucky held onto the ball for more than 34 minutes and ran 22 more plays. Clemson still outgained the Wildcats 321-277 and the Tigers held on to the ball for the final 5:27.
Winds gusting to 22 mph affected both teams on a cold night.
Richard Jackson's 44-yard field goal for Clemson into the wind came up just short with 4:32 left in the third. Kentucky called a timeout with 2 seconds left in the third, and Dawson Zimmerman's punt went just 24 yards before bouncing back for the Wildcats.
The Tigers forced Kentucky three-and-out, and Tydlacka had to deal with that wind himself. His punt went only 14 yards.
Clemson led 14-10 at halftime as Kyle Parker found Jacoby Ford all alone in the end zone for a 32-yard TD pass to cap a four-play, 90-yard drive Spiller jumpstarted with a 42-yard catch-and-run.
Seiber put Kentucky up 10-7 in the second with a 39-yard field goal, then Spiller had a 30-yard kickoff return. Tailback Jamie Harper handled all the work on a five-play drive as he picked up 60 yards and capped it with a 1-yard plunge to put the Tigers ahead 14-10 in the second quarter.
The Wildcats' only TD came on their opening drive when Newton found Chris Matthews in the end zone for a 17-yard TD pass and a 7-0 lead.
STATISTICS
FIRST QUARTER
Ky_Matthews 17 pass from Newton (Seiber kick), 10:08.
Clem_J.Ford 32 pass from Parker (Jackson kick), :16.
SECOND QUARTER
Ky_FG Seiber 39, 7:29.
Clem_Harper 1 run (Jackson kick), 5:19.
THIRD QUARTER
Ky_FG Seiber 44, 10:13.
FOURTH QUARTER
Clem_Spiller 8 run (Jackson kick), 10:14.
A_57,280.
INDIVIDUAL STATISTICS
RUSHING_Kentucky, Locke 18-64, Newton 10-37, R.Cobb 10-36, Allen 2-19, Tydlacka 1-9, Conner 1-2. Clemson, Harper 8-79, Spiller 15-67, Ellington 4-20, Parker 3-16, J.Ford 1-2, Team 2-(minus 4).
PASSING_Kentucky, Newton 13-23-0-98, R.Cobb 2-3-0-12. Clemson, Parker 8-14-0-141.
RECEIVING_Kentucky, Locke 6-30, McCaskill 4-31, R.Cobb 2-20, Grinter 2-12, Matthews 1-17. Clemson, Spiller 3-58, J.Ford 3-44, Palmer 2-39.
KENTUCKY7330--13CLEMSON7707--21KYCLEMFirst Downs1914Rushes42-16733-180Passing110141Return Yards-20Punts-Avg4-29.34-36.5Comp-Att-Int15-26-08-14-0Fumbles - Lost1-12-0Penalties - Yards3-157-75Time of Poss.34:2625:34